The patients with a specialist diagnose of chronic non-malignant and carcinoma pain of the locomotor system are examined and released from the pain successively. Also, a part of the patients are transferred to the Clinical Center - Skopje for additional laboratory, radiological and subspecialistic surgical and internal examinations.      The following, more frequent syndromes of chronic pain are treated by planned methods of pain release:  degenerative diseases of the muscle-sceletal system and spine, rheumatic diseases of the spine and joints, muscle-skeletal pains during mialgia, miositis, fibromiositis, fascities, tendinitis and bursitis, neuralgic pain caused by degenerative, inflammatory, circular, toxic and compressive diseases, postrauma dystrophy of the soft tissues and osteoarticular system, vasospastic diseases (Birger's and Rajan's disease), Scalenus syndrome, Herpes Zoster and postherapeutic neuralgia, Malignant-carcinoma diseases.     Which method of the pain release will be applied and administered in the patients- should mainly depend od the: grade and type of the pain, duration of the pain and disease, age and general condition of patients, type and time of previously consumed analgesics and other medicaments, eventual presence of allergic dietesis of  the patients.      In the Pain Center, the following most frequent pain releases will be applied:  intravenous- infusion and intramuscular administration of combination of non-steroid and steroid  analgesics with polyvitamins, tranquilizers and antireumatics, one- time or continuos application off regional and local anaethesias and block of nerves, nerve plexuses and ganglions by the help of contemporary  local  anaesthetics, intraarticular applications of local anaesthetics and other medicaments, transcutaneous baterial nerve stimulation- TENS, massage and physical therapy.